OR5AS1

Across TCGA patient cohorts, OR5AS1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR5AS1-associated genes across cancer lineages are Notch1, Shc_pY317, and Caspase-7-cleavedD198. Each is linked with OR5AS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR5AS1-to-partner and partner-to-OR5AS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by OR5AS1-low versus OR5AS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR5AS1→partner) and Y-score (partner→OR5AS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.171	+2.009	<.001	.017	3	2
UCEC	Shc_pY317 →	-0.124	-1.502	.026	.030	3	2
UCEC	Caspase-7-cleavedD198 →	+0.448	+1.894	.039	.030	3	2
UCEC	4E-BP1 →	+0.251	+2.321	.011	.033	3	2
UCEC	EGFR_pY1068 →	-0.213	-2.222	.020	.010	3	1
UCEC	eIF4E →	+0.172	+2.247	.026	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Notch1 by OR5AS1 expression — UCEC

Explore this box plot interactively →