OR5AK2

Across TCGA patient cohorts, OR5AK2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR5AK2-associated genes across cancer lineages are Caspase-8, C-Raf, and FoxM1. Each is linked with OR5AK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR5AK2-to-partner and partner-to-OR5AK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by OR5AK2-low versus OR5AK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR5AK2→partner) and Y-score (partner→OR5AK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.293	-3.295	.012	.009	3	2
UCEC	C-Raf →	+0.191	+2.584	.004	.011	3	2
UCEC	FoxM1 →	+0.295	+2.584	.014	.011	3	2
SKCM	NDRG1_pT346 →	-0.445	-1.584	.047	.032	3	1
SKCM	NF-kB-p65_pS536 →	+0.338	+2.222	.010	.008	3	1
SKCM	p21 →	-0.291	-3.169	.048	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Caspase-8 by OR5AK2 expression — UCEC

Explore this box plot interactively →