Across TCGA pan-cancer cohorts, OR56A5 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of OR56A5’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where OR56A5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OR56A5 is over-expressed in tumor.
HNSC and LUSC are the cancer types where OR56A5 tumor–normal differential expression is most reproducible.