Across TCGA pan-cancer cohorts, OR52W1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of OR52W1’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where OR52W1 RNA is repressed in tumor relative to normal tissue. In most cancer types OR52W1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
THCA and STAD are the cancer types where OR52W1 tumor–normal differential expression is most reproducible.