Across TCGA pan-cancer cohorts, OR52M2P RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of OR52M2P’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where OR52M2P RNA is repressed in tumor relative to normal tissue. In most cancer types OR52M2P is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.
LUAD and LUSC are the cancer types where OR52M2P tumor–normal differential expression is most reproducible.