Across TCGA pan-cancer cohorts, OR52H2P RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of OR52H2P’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where OR52H2P RNA is repressed in tumor relative to normal tissue. In most cancer types OR52H2P is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.
LUSC and KIRC are the cancer types where OR52H2P tumor–normal differential expression is most reproducible.