OR52E2

Across TCGA patient cohorts, OR52E2 mutation is significantly associated with the RNA expression of many other genes, with 1,379 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR52E2-associated genes across cancer lineages are EBF1, SCN4B, and PLCD1. Each is linked with OR52E2 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR52E2-to-partner and partner-to-OR52E2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EBF1 grouped by OR52E2-low versus OR52E2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR52E2→partner) and Y-score (partner→OR52E2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	EBF1 →	-0.539	-3.447	.008	.005	3	3
SKCM	SCN4B →	-0.596	-2.392	.004	<.001	3	3
UCEC	PLCD1 →	-0.672	-3.127	<.001	<.001	3	3
HNSC	RPL12P46 →	+0.156	+4.505	.005	.009	3	2
LUSC	SNRPA1 →	+0.460	+3.471	.003	.002	2	3
LUSC	ATG10 →	+0.445	+3.459	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,379 associations by consensus.

EBF1 by OR52E2 expression — LUSC

Explore this box plot interactively →