OR52E2

Across TCGA patient cohorts, OR52E2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR52E2-associated genes across cancer lineages are 4E-BP1, FoxM1, and p62 Lck ligand. Each is linked with OR52E2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR52E2-to-partner and partner-to-OR52E2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by OR52E2-low versus OR52E2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR52E2→partner) and Y-score (partner→OR52E2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.280	+2.351	.012	.018	3	2
UCEC	FoxM1 →	+0.226	+2.999	.034	.035	3	2
UCEC	p62 Lck ligand →	+0.430	+3.710	.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.674	+2.341	.005	.019	3	2
SKCM	PI3K-p85 →	+0.188	+1.919	.008	.008	3	1
SKCM	PTEN →	+0.313	+3.169	.017	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

4E-BP1 by OR52E2 expression — UCEC

Explore this box plot interactively →