OR52B2

Across TCGA patient cohorts, OR52B2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible OR52B2-associated genes across cancer lineages are 4E-BP1_pT37_T46, A-Raf_pS299, and G6PD. Each is linked with OR52B2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR52B2-to-partner and partner-to-OR52B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pT37_T46 grouped by OR52B2-low versus OR52B2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR52B2→partner) and Y-score (partner→OR52B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	4E-BP1_pT37_T46 →	+0.480	+3.000	.037	.036	3	2
LUSC	A-Raf_pS299 →	+0.392	+2.816	.004	.036	3	1
SKCM	G6PD →	-0.289	-3.000	.015	.036	3	1
SKCM	HER3 →	+0.490	+3.017	.038	.019	3	1
SKCM	Dvl3 →	+0.338	+3.000	.004	.035	3	1
SKCM	Caspase-8 →	-0.225	-3.000	.006	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

4E-BP1_pT37_T46 by OR52B2 expression — SKCM

Explore this box plot interactively →