OR52A5

Across TCGA patient cohorts, OR52A5 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR52A5-associated genes across cancer lineages are Ku80, NDRG1_pT346, and 53BP1. Each is linked with OR52A5 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR52A5-to-partner and partner-to-OR52A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by OR52A5-low versus OR52A5-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR52A5→partner) and Y-score (partner→OR52A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Ku80 →	+0.383	+2.486	.009	.010	3	2
LUSC	NDRG1_pT346 →	-1.025	-3.169	.008	.018	3	2
LUSC	53BP1 →	+0.540	+3.000	.002	.035	3	2
UCEC	JNK2 →	+0.331	+3.331	<.001	.005	3	2
UCEC	Cyclin-B1 →	+0.740	+3.000	.006	.036	3	2
SKCM	p90 RSK →	+0.277	+2.321	.002	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Ku80 by OR52A5 expression — LUSC

Explore this box plot interactively →