OR52A1

Across TCGA patient cohorts, OR52A1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR52A1-associated genes across cancer lineages are Notch1, Smac, and Src. Each is linked with OR52A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR52A1-to-partner and partner-to-OR52A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by OR52A1-low versus OR52A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR52A1→partner) and Y-score (partner→OR52A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.138	+2.820	.025	.035	3	2
SKCM	Smac →	+0.251	+1.749	.033	.049	3	1
SKCM	Src →	-0.252	-2.321	.011	.033	3	1
SKCM	CD49b →	+0.398	+1.602	<.001	.042	3	1
UCEC	EGFR_pY1068 →	-0.287	-2.321	.008	.034	3	1
UCEC	mTOR →	-0.180	-2.115	.010	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Notch1 by OR52A1 expression — UCEC

Explore this box plot interactively →