Across TCGA pan-cancer cohorts, OR51J1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of OR51J1’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where OR51J1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OR51J1 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.
THCA and LUSC are the cancer types where OR51J1 tumor–normal differential expression is most reproducible.