Across TCGA pan-cancer cohorts, OR51I1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of OR51I1’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where OR51I1 RNA is repressed in tumor relative to normal tissue. In most cancer types OR51I1 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.
LUSC, COAD, and LIHC are the cancer types where OR51I1 tumor–normal differential expression is most reproducible.