Across TCGA pan-cancer cohorts, OR51A4 Mutation is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated OR51A4 data layer compared with 4 for mass-spec protein.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher OR51A4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated OR51A4 expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCEC show a favorable association.
LUSC, HNSC, and ACC are the cancer types where OR51A4 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.