OR4X1

Across TCGA patient cohorts, OR4X1 mutation is significantly associated with the RNA expression of many other genes, with 1,533 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4X1-associated genes across cancer lineages are RNU6-492P, TMEM251, and GATAD2A. Each is linked with OR4X1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4X1-to-partner and partner-to-OR4X1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-492P grouped by OR4X1-low versus OR4X1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4X1→partner) and Y-score (partner→OR4X1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-492P →	+0.478	+7.954	<.001	.008	3	2
UCEC	TMEM251 →	+0.579	+2.601	.002	.006	3	2
UCEC	GATAD2A →	+0.483	+2.343	.002	.003	3	2
UCEC	DAPK3 →	+0.431	+2.593	.007	.006	3	2
UCEC	CHAF1A →	+0.687	+3.502	<.001	.002	3	2
UCEC	RAD51 →	+0.653	+3.470	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,533 associations by consensus.

RNU6-492P by OR4X1 expression — HNSC

Explore this box plot interactively →