OR4S2

Across TCGA pan-cancer cohorts, OR4S2 Mutation is linked to patient survival in 5 of 34 cancer types, making it the most broadly survival-associated OR4S2 data layer compared with 4 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher OR4S2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated OR4S2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

CESC, STAD, and UCEC are the cancer types where OR4S2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	All	0.121	0.875	<.001	48	view →
STAD	DFS	Median	All	0.219	0.714	.001	15	view →
UCEC	DFS	Median	All	1.000	0.630	.037	4	view →
LUSC	DFS	Median	II,III,IV	0.135	0.663	.015	3	view →
SKCM	DFS	Median	III,IV	0.898	0.575	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

OR4S2–CESC (OS)

Open the CESC breakdown →