OR4S2

Across TCGA patient cohorts, OR4S2 mutation is significantly associated with the RNA expression of many other genes, with 2,848 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible OR4S2-associated genes across cancer lineages are OFD1P16Y, ZNF77, and OTX1. Each is linked with OR4S2 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR4S2-to-partner and partner-to-OR4S2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OFD1P16Y grouped by OR4S2-low versus OR4S2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4S2→partner) and Y-score (partner→OR4S2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OFD1P16Y →	+0.439	+1.759	<.001	<.001	3	3
UCEC	ZNF77 →	+0.546	+2.732	.001	.003	3	3
LUSC	OTX1 →	+0.901	+3.333	.004	.005	3	3
LUAD	IFRD1 →	+0.689	+2.712	.001	.003	3	3
UCEC	VWA1 →	-1.285	-3.796	<.001	<.001	3	3
UCEC	ANAPC1P2 →	+0.504	+2.754	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,848 associations by consensus.

OFD1P16Y by OR4S2 expression — SKCM

Explore this box plot interactively →