OR4S2

Across TCGA patient cohorts, OR4S2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4S2-associated genes across cancer lineages are MEK1, MAPK_pT202_Y204, and Akt_pT308. Each is linked with OR4S2 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR4S2-to-partner and partner-to-OR4S2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by OR4S2-low versus OR4S2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4S2→partner) and Y-score (partner→OR4S2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.381	+3.000	.031	.036	3	3
LUAD	MAPK_pT202_Y204 →	-0.401	-3.321	.035	.010	3	1
LUAD	Akt_pT308 →	-0.255	-3.000	.018	.035	3	1
LUAD	S6_pS235_S236 →	-0.542	-3.321	.009	.010	3	1
UCEC	EGFR_pY1068 →	-0.309	-3.584	.010	.002	3	1
UCEC	GATA6 →	-0.179	-2.985	.016	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

MEK1 by OR4S2 expression — UCEC

Explore this box plot interactively →