OR4S2

Across TCGA cell cohorts, OR4S2 mutation is significantly associated with the mutation status of many other genes, with 486 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible OR4S2-associated genes across cancer lineages are ACP3, KDM4B, and ALOXE3. Each is linked with OR4S2 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR4S2-to-partner and partner-to-OR4S2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACP3 grouped by OR4S2-low versus OR4S2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4S2→partner) and Y-score (partner→OR4S2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ACP3 →	+5.824	+5.824	.002	.002	1	3
SOFT_TISSUE	KDM4B →	+5.066	+4.502	.007	.007	1	3
SKIN	ALOXE3 →	+4.239	+5.053	.007	.007	1	2
SKIN	TMEM259 →	+4.824	+5.392	.004	.004	1	2
LUNG_NSCLC_LUAD	BPIFB4 →	+5.772	+5.772	.002	.002	1	2
SKIN	RPL10A →	+5.824	+5.824	.002	.002	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 486 associations by consensus.

ACP3 by OR4S2 expression — SKIN

Explore this box plot interactively →