OR4S1

Across TCGA pan-cancer cohorts, OR4S1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated OR4S1 data layer compared with 10 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher OR4S1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated OR4S1 expression acts as an unfavorable survival marker, although some lineages such as LUSC show a favorable association.

COAD, READ, and LGG are the cancer types where OR4S1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.113	0.705	<.001	48	view →
READ	DFS	Median	III,IV	0.255	0.757	.008	9	view →
LGG	DFS	Median	All	0.418	0.848	.004	6	view →
LUSC	DFS	Median	All	1.000	0.388	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

OR4S1–COAD (DFS)

Open the COAD breakdown →