OR4Q3

Across TCGA patient cohorts, OR4Q3 mutation is significantly associated with the RNA expression of many other genes, with 951 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4Q3-associated genes across cancer lineages are TESK1, SLC25A11, and MRPL50. Each is linked with OR4Q3 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR4Q3-to-partner and partner-to-OR4Q3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TESK1 grouped by OR4Q3-low versus OR4Q3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4Q3→partner) and Y-score (partner→OR4Q3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TESK1 →	+0.434	+3.010	.006	<.001	3	3
SCLC	SLC25A11 →	+2.703	+2.365	.006	.008	3	2
SCLC	MRPL50 →	+0.498	+3.207	.004	.006	3	2
ESCA	HBZP1 →	+0.099	+5.247	<.001	.006	3	2
SKCM	RNU6-1003P →	+0.054	+2.797	.002	.008	3	2
BRCA	RNY4P13 →	+0.989	+6.112	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 951 associations by consensus.

TESK1 by OR4Q3 expression — UCEC

Explore this box plot interactively →