OR4Q3

Across TCGA patient cohorts, OR4Q3 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4Q3-associated genes across cancer lineages are EGFR_pY1068, MEK1_p_S217_S221, and JNK_pT183_Y185. Each is linked with OR4Q3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4Q3-to-partner and partner-to-OR4Q3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by OR4Q3-low versus OR4Q3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4Q3→partner) and Y-score (partner→OR4Q3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.263	-2.584	.024	.011	3	2
SKCM	MEK1_p_S217_S221 →	+0.234	+3.000	.015	.034	3	2
UCEC	JNK_pT183_Y185 →	-0.187	-3.000	.017	.036	2	2
UCEC	AR →	-0.383	-2.584	.027	.011	3	1
UCEC	4E-BP1_pS65 →	-0.196	-2.571	.031	.011	3	1
UCEC	4E-BP1_pT37_T46 →	-0.446	-3.156	.010	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by OR4Q3 expression — UCEC

Explore this box plot interactively →