OR4Q3

Across TCGA cell cohorts, OR4Q3 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible OR4Q3-associated genes across cancer lineages are SLC10A2, ASCL3, and NUTM1. Each is linked with OR4Q3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4Q3-to-partner and partner-to-OR4Q3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC10A2 grouped by OR4Q3-low versus OR4Q3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4Q3→partner) and Y-score (partner→OR4Q3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLC10A2 →	+0.004	+4.437	<.001	.004	3	1
SKIN	ASCL3 →	+0.099	+3.914	<.001	.005	3	1
SKIN	NUTM1 →	+0.023	+4.459	<.001	.003	3	1
SKIN	ANKRD66 →	+0.009	+4.217	.001	.001	3	1
LUNG_SCLC	OR52N2 →	+0.141	+4.044	<.001	.009	3	1
LUNG_SCLC	FAM9A →	+0.214	+4.044	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

SLC10A2 by OR4Q3 expression — SKIN

Explore this box plot interactively →