Across TCGA pan-cancer cohorts, OR4N4 Mutation is linked to patient survival in 5 of 34 cancer types, making it the most broadly survival-associated OR4N4 data layer compared with 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher OR4N4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated OR4N4 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

HNSC, LUAD, and READ are the cancer types where OR4N4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.116	0.710	<.001	48	view →
LUAD	OS	Median	II,III,IV	0.153	0.750	<.001	22	view →
READ	DFS	Median	All	0.112	0.845	.001	12	view →
SKCM	DFS	Median	All	0.136	0.757	.006	8	view →
GBM	DFS	Median	All	1.000	0.248	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: OR4N4 tumor-vs-normal RNA expression · all OR4N4 data types