OR4N2

Across TCGA patient cohorts, OR4N2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4N2-associated genes across cancer lineages are PCNA, Notch1, and Cyclin-B1. Each is linked with OR4N2 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR4N2-to-partner and partner-to-OR4N2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by OR4N2-low versus OR4N2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4N2→partner) and Y-score (partner→OR4N2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.253	+2.502	.002	.002	3	3
UCEC	Notch1 →	+0.254	+3.820	<.001	<.001	3	2
UCEC	Cyclin-B1 →	+0.888	+3.169	<.001	<.001	3	2
SKCM	Akt_pT308 →	+0.514	+1.713	.004	.024	3	2
UCEC	14-3-3_beta →	-0.081	-1.847	.040	.049	3	1
UCEC	eIF4G →	+0.313	+2.999	.010	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

PCNA by OR4N2 expression — UCEC

Explore this box plot interactively →