OR4N2

Across TCGA cell cohorts, OR4N2 mutation is significantly associated with the RNA expression of many other genes, with 287 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OR4N2-associated genes across cancer lineages are FRG1, OR8B3, and DEFB105A. Each is linked with OR4N2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4N2-to-partner and partner-to-OR4N2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FRG1 grouped by OR4N2-low versus OR4N2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4N2→partner) and Y-score (partner→OR4N2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FRG1 →	+0.447	+3.169	.002	.009	3	2
OESOPHAGUS	OR8B3 →	+0.026	+4.392	<.001	.003	3	1
LUNG_SCLC	DEFB105A →	+0.200	+5.643	<.001	.002	3	1
LUNG_SCLC	IFNA7 →	+0.340	+5.643	<.001	.002	3	1
LUNG_SCLC	IFNA4 →	+0.182	+5.029	<.001	.006	3	1
LARGE_INTESTINE	MCAT →	+0.783	+3.252	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 287 associations by consensus.

FRG1 by OR4N2 expression — LARGE_INTESTINE

Explore this box plot interactively →