OR4L1

Across TCGA patient cohorts, OR4L1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4L1-associated genes across cancer lineages are Cyclin-B1, Rab25, and ER-alpha_pS118. Each is linked with OR4L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4L1-to-partner and partner-to-OR4L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by OR4L1-low versus OR4L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4L1→partner) and Y-score (partner→OR4L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.654	+2.115	.007	.019	3	2
SKCM	Rab25 →	-0.249	-3.296	.033	.009	3	2
LUSC	ER-alpha_pS118 →	-0.092	-3.276	.048	.010	2	2
LUSC	Raptor →	+0.230	+2.825	.024	.033	3	1
UCEC	MEK1 →	+0.497	+2.115	.001	.019	3	1
UCEC	Notch1 →	+0.202	+2.115	.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Cyclin-B1 by OR4L1 expression — UCEC

Explore this box plot interactively →