OR4K3

Across TCGA pan-cancer cohorts, OR4K3 RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated OR4K3 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher OR4K3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated OR4K3 expression acts as an unfavorable survival marker, although some lineages such as LGG show a favorable association.

KIRP, PAAD, and THCA are the cancer types where OR4K3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.187	0.700	<.001	60	view →
PAAD	OS	Tertile	All	0.037	0.641	<.001	54	view →
THCA	DFS	Tertile	III,IV	0.114	0.740	.001	54	view →
HNSC	OS	Tertile	All	0.246	0.605	.022	36	view →
LUSC	DFS	Tertile	III,IV	0.079	0.658	<.001	36	view →
LIHC	OS	Tertile	III,IV	0.092	0.649	<.001	36	view →
DLBC	OS	Tertile	III,IV	0.175	0.874	.025	27	view →
MESO	OS	Tertile	IV	0.077	0.592	.019	18	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	9	view →
LGG	OS	Median	All	0.927	0.859	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

OR4K3–KIRP (OS)

Open the KIRP breakdown →