OR4K2

Across TCGA patient cohorts, OR4K2 mutation is significantly associated with the RNA expression of many other genes, with 3,585 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4K2-associated genes across cancer lineages are FCER1A, GBGT1, and FGD5. Each is linked with OR4K2 in more than 3 cancer types. Because this analysis shows association rather than direction, both OR4K2-to-partner and partner-to-OR4K2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCER1A grouped by OR4K2-low versus OR4K2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4K2→partner) and Y-score (partner→OR4K2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FCER1A →	-0.645	-1.925	.006	.005	3	4
SKCM	GBGT1 →	-0.469	-1.565	.003	.004	3	4
SKCM	FGD5 →	-0.521	-1.980	<.001	<.001	3	4
UCEC	LINC00449 →	+0.334	+4.008	<.001	<.001	3	3
UCEC	FASTKD5 →	+0.426	+2.595	.005	.005	3	3
LUAD	NFATC2 →	-0.639	-3.573	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,585 associations by consensus.

FCER1A by OR4K2 expression — UCEC

Explore this box plot interactively →