OR4K2

Across TCGA patient cohorts, OR4K2 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4K2-associated genes across cancer lineages are p38-MAPK, PREX1, and p38-MAPK_pT180_Y182. Each is linked with OR4K2 in more than 3 cancer types. Because this analysis shows association rather than direction, both OR4K2-to-partner and partner-to-OR4K2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK grouped by OR4K2-low versus OR4K2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4K2→partner) and Y-score (partner→OR4K2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	p38-MAPK →	-0.189	-3.000	.013	.035	2	4
SKCM	PREX1 →	-0.301	-2.502	.003	.001	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.572	-3.700	<.001	.001	2	3
UCEC	FASN →	+0.395	+2.459	.007	.019	3	2
UCEC	FoxM1 →	+0.192	+2.169	.047	.003	3	2
UCEC	Notch1 →	+0.206	+1.916	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

p38-MAPK by OR4K2 expression — LUAD

Explore this box plot interactively →