OR4K17

Across TCGA patient cohorts, OR4K17 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4K17-associated genes across cancer lineages are 4E-BP1, PKC-b-II_pS660, and Snail. Each is linked with OR4K17 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR4K17-to-partner and partner-to-OR4K17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by OR4K17-low versus OR4K17-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4K17→partner) and Y-score (partner→OR4K17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	4E-BP1 →	+0.331	+3.000	.043	.036	3	3
LUAD	PKC-b-II_pS660 →	-0.457	-3.000	.034	.036	3	2
SKCM	Snail →	+0.145	+2.584	.021	.009	3	2
UCEC	mTOR_pS2448 →	-0.181	-2.986	.012	.035	3	2
UCEC	C-Raf →	+0.301	+3.584	<.001	.002	3	2
LUAD	c-Myc →	+0.308	+3.000	.006	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

4E-BP1 by OR4K17 expression — LUAD

Explore this box plot interactively →