OR4K13

Across TCGA patient cohorts, OR4K13 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4K13-associated genes across cancer lineages are 4E-BP1_pS65, 4E-BP1_pT70, and Cyclin-E2. Each is linked with OR4K13 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4K13-to-partner and partner-to-OR4K13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pS65 grouped by OR4K13-low versus OR4K13-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4K13→partner) and Y-score (partner→OR4K13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	4E-BP1_pS65 →	+0.334	+3.012	<.001	.018	2	2
LUAD	4E-BP1_pT70 →	+0.190	+2.186	.044	.034	3	1
LUAD	Cyclin-E2 →	+0.189	+2.824	.004	.034	3	1
UCEC	GATA3 →	+0.206	+3.020	.037	.019	3	1
UCEC	INPP4B →	-0.378	-3.169	.025	.019	3	1
UCEC	MSH2 →	-0.277	-2.990	.021	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

4E-BP1_pS65 by OR4K13 expression — LUAD

Explore this box plot interactively →