OR4K1

Across TCGA pan-cancer cohorts, OR4K1 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated OR4K1 data layer compared with 12 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher OR4K1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated OR4K1 expression acts as an unfavorable survival marker, although some lineages such as SCLC and LUSC show a favorable association.

READ, UVM, and SCLC are the cancer types where OR4K1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	II,III,IV	0.111	0.919	<.001	45	view →
UVM	OS	Median	II,III,IV	0.213	0.718	.002	27	view →
SCLC	DFS	Median	II,III,IV	1.000	0.299	.018	13	view →
HNSC	OS	Median	All	0.151	0.685	.007	3	view →
BLCA	OS	Median	III,IV	0.188	0.654	.015	3	view →
COAD	OS	Median	All	0.546	0.872	.020	2	view →
LUSC	OS	Median	II,III,IV	1.000	0.731	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

OR4K1–READ (OS)

Open the READ breakdown →