OR4K1

Across TCGA patient cohorts, OR4K1 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4K1-associated genes across cancer lineages are CD31, Chk2_pT68, and p21. Each is linked with OR4K1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4K1-to-partner and partner-to-OR4K1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD31 grouped by OR4K1-low versus OR4K1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4K1→partner) and Y-score (partner→OR4K1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD31 →	-0.141	-2.222	.024	.011	3	2
UCEC	Chk2_pT68 →	-0.159	-3.160	.044	.019	3	2
SKCM	p21 →	-0.501	-2.000	.002	.029	3	2
SKCM	SF2 →	-0.164	-2.906	.001	.001	3	2
LUSC	Cyclin-E2 →	+0.134	+2.825	.033	.033	3	1
UCEC	14-3-3_beta →	-0.127	-3.295	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

CD31 by OR4K1 expression — UCEC

Explore this box plot interactively →