OR4K1

Across TCGA cell cohorts, OR4K1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OR4K1-associated genes across cancer lineages are CATSPERD, C5orf52, and RNASE8. Each is linked with OR4K1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4K1-to-partner and partner-to-OR4K1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CATSPERD grouped by OR4K1-low versus OR4K1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4K1→partner) and Y-score (partner→OR4K1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CATSPERD →	+0.076	+4.263	.001	.002	3	1
LUNG_SCLC	C5orf52 →	+0.052	+4.643	<.001	.004	3	1
LUNG_NSCLC_LUAD	RNASE8 →	+0.046	+5.189	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR6B3 →	+0.019	+4.734	.002	.002	3	1
LARGE_INTESTINE	CFHR2 →	+0.038	+4.022	<.001	.006	3	1
LARGE_INTESTINE	ADAMTS4 →	+0.106	+3.626	.007	.006	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

CATSPERD by OR4K1 expression — SKIN

Explore this box plot interactively →