Across TCGA patient cohorts, OR4F6 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4F6-associated genes across cancer lineages are EGFR_pY1068, GAPDH, and JNK2. Each is linked with OR4F6 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4F6-to-partner and partner-to-OR4F6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4F6→partner) and Y-score (partner→OR4F6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.289	-3.169	.008	.018	3	1
UCEC	GAPDH →	+0.524	+2.115	.025	.019	3	1
UCEC	JNK2 →	+0.251	+3.009	.003	.019	3	1
UCEC	MEK1 →	+0.395	+2.999	.013	.035	3	1
UCEC	Notch1 →	+0.180	+2.115	.003	.019	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.662	-2.102	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

OR4F6 survival (RNA) · tumor vs normal (RNA) · all OR4F6 data types