OR4F4

Across TCGA patient cohorts, OR4F4 mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4F4-associated genes across cancer lineages are RNA5SP411, RNA5SP412, and IGFL3. Each is linked with OR4F4 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4F4-to-partner and partner-to-OR4F4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP411 grouped by OR4F4-low versus OR4F4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4F4→partner) and Y-score (partner→OR4F4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP411 →	+2.461	+3.130	<.001	.003	3	1
UCEC	RNA5SP412 →	+1.472	+3.704	<.001	<.001	3	1
UCEC	IGFL3 →	+0.652	+3.078	<.001	.005	3	1
UCEC	RNA5SP405 →	+0.378	+3.997	<.001	.009	3	1
UCEC	RNY1P16 →	+0.986	+3.561	<.001	.001	3	1
UCEC	RNU6-618P →	+0.398	+3.384	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

RNA5SP411 by OR4F4 expression — UCEC

Explore this box plot interactively →