OR4D6

Across TCGA patient cohorts, OR4D6 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible OR4D6-associated genes across cancer lineages are Caspase-7-cleavedD198, MIG-6, and p70-S6K. Each is linked with OR4D6 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4D6-to-partner and partner-to-OR4D6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by OR4D6-low versus OR4D6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4D6→partner) and Y-score (partner→OR4D6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.819	+3.341	.002	.005	3	2
LUAD	MIG-6 →	+0.277	+2.459	.002	.020	3	1
LUAD	p70-S6K →	+0.198	+3.000	.043	.035	3	1
LUAD	PI3K-p110-a →	+0.142	+3.186	.008	.009	3	1
LUAD	Rab11 →	-0.196	-2.459	.002	.020	3	1
LUAD	Dvl3 →	+0.155	+3.601	.032	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Caspase-7-cleavedD198 by OR4D6 expression — UCEC

Explore this box plot interactively →