OR4D5

Across TCGA cell cohorts, OR4D5 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible OR4D5-associated genes across cancer lineages are SIGLEC5, AADACL3, and ADIPOQ. Each is linked with OR4D5 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4D5-to-partner and partner-to-OR4D5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC5 grouped by OR4D5-low versus OR4D5-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4D5→partner) and Y-score (partner→OR4D5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SIGLEC5 →	+0.029	+5.415	<.001	.004	3	1
SKIN	AADACL3 →	+0.006	+4.977	<.001	.007	3	1
BLOOD_Lymphoma	ADIPOQ →	+0.013	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	AADACL2 →	+0.020	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	TLE7 →	+0.016	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	ZNF728 →	+1.130	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

SIGLEC5 by OR4D5 expression — SKIN

Explore this box plot interactively →