OR4D5

Across TCGA cell cohorts, OR4D5 mutation is significantly associated with the mutation status of many other genes, with 460 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OR4D5-associated genes across cancer lineages are EDNRB, GALNT18, and IL1RL1. Each is linked with OR4D5 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4D5-to-partner and partner-to-OR4D5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EDNRB grouped by OR4D5-low versus OR4D5-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4D5→partner) and Y-score (partner→OR4D5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	EDNRB →	+4.228	+4.228	.004	.004	1	2
LUNG_NSCLC_LUAD	GALNT18 →	+4.924	+5.584	<.001	<.001	1	2
LUNG_NSCLC_LUAD	IL1RL1 →	+4.339	+4.339	.009	.009	1	2
LUNG_NSCLC_LUAD	HTR7 →	+3.339	+4.662	.003	.003	1	2
SKIN	DLG4 →	+5.824	+5.824	.002	.002	1	2
BREAST	SAMD9L →	+4.297	+4.857	.009	.009	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 460 associations by consensus.

EDNRB by OR4D5 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →