Across TCGA patient cohorts, OR4C46 mutation is significantly associated with the RNA expression of many other genes, with 3,364 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4C46-associated genes across cancer lineages are TCF3, POLE2, and CKAP2. Each is linked with OR4C46 in more than 3 cancer types. Because this analysis shows association rather than direction, both OR4C46-to-partner and partner-to-OR4C46 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4C46→partner) and Y-score (partner→OR4C46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TCF3 →	+0.782	+2.828	<.001	.001	3	4
LUAD	POLE2 →	+0.750	+2.674	<.001	<.001	3	4
LUAD	CKAP2 →	+0.574	+3.631	.001	.001	3	4
LUAD	LCLAT1 →	+0.431	+3.690	<.001	.001	3	4
UCEC	CEP57L1 →	+0.525	+3.212	<.001	.009	3	4
SKCM	ITGB1BP1 →	+0.581	+2.616	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,364 associations by consensus.

Exploration

OR4C46 survival (RNA) · tumor vs normal (RNA) · all OR4C46 data types