Across TCGA patient cohorts, OR4C46 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4C46-associated genes across cancer lineages are AMPK_alpha, ASNS, and c-Myc. Each is linked with OR4C46 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR4C46-to-partner and partner-to-OR4C46 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4C46→partner) and Y-score (partner→OR4C46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AMPK_alpha →	-0.200	-2.321	.036	.035	3	3
LUAD	ASNS →	+0.723	+2.459	<.001	.018	3	2
LUAD	c-Myc →	+0.205	+2.700	.021	.006	3	2
UCEC	MIG-6 →	+0.118	+2.817	.018	.036	2	3
UCEC	PDCD4 →	-0.816	-3.459	<.001	.005	3	2
UCEC	PKC-b-II_pS660 →	-0.313	-2.321	.024	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration

OR4C46 survival (RNA) · tumor vs normal (RNA) · all OR4C46 data types