OR4C3

Across TCGA patient cohorts, OR4C3 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4C3-associated genes across cancer lineages are AR, eEF2, and AMPK_alpha. Each is linked with OR4C3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4C3-to-partner and partner-to-OR4C3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AR grouped by OR4C3-low versus OR4C3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4C3→partner) and Y-score (partner→OR4C3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AR →	-0.483	-2.321	.009	.035	3	2
SKCM	eEF2 →	+0.346	+2.321	.015	.033	3	1
SKCM	AMPK_alpha →	+0.253	+3.807	<.001	<.001	3	1
UCEC	JNK_pT183_Y185 →	-0.173	-2.308	.041	.036	3	1
UCEC	Notch1 →	+0.279	+2.820	<.001	.035	3	1
UCEC	Annexin-1 →	+0.534	+2.321	.043	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

AR by OR4C3 expression — UCEC

Explore this box plot interactively →