OR4C3

Across TCGA cell cohorts, OR4C3 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OR4C3-associated genes across cancer lineages are OXT, TEX43, and IFNL4. Each is linked with OR4C3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4C3-to-partner and partner-to-OR4C3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OXT grouped by OR4C3-low versus OR4C3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4C3→partner) and Y-score (partner→OR4C3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OXT →	+0.041	+3.562	<.001	.002	3	1
SKIN	TEX43 →	+0.071	+3.217	.001	.006	3	1
SKIN	IFNL4 →	+0.045	+3.297	<.001	.002	3	1
LUNG_SCLC	GPR65 →	+0.077	+4.129	<.001	.001	3	1
LUNG_SCLC	SLAMF9 →	+0.334	+3.603	.005	.002	3	1
LUNG_SCLC	C11orf86 →	+0.139	+2.754	.009	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

OXT by OR4C3 expression — SKIN

Explore this box plot interactively →