Across TCGA pan-cancer cohorts, OR4C12 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of OR4C12’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where OR4C12 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OR4C12 is over-expressed in tumor.
HNSC and PRAD are the cancer types where OR4C12 tumor–normal differential expression is most reproducible.