OR4B1

Across TCGA patient cohorts, OR4B1 mutation is significantly associated with the RNA expression of many other genes, with 763 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible OR4B1-associated genes across cancer lineages are MIR4425, RNU6-1146P, and RPEL1. Each is linked with OR4B1 in more than 3 cancer types. Because this analysis shows association rather than direction, both OR4B1-to-partner and partner-to-OR4B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4425 grouped by OR4B1-low versus OR4B1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4B1→partner) and Y-score (partner→OR4B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR4425 →	+0.731	+5.136	<.001	.002	3	4
BLCA	RNU6-1146P →	+0.523	+4.497	<.001	.009	3	3
SKCM	RPEL1 →	+0.046	+1.830	.002	.002	3	2
SKCM	NDUFA4P2 →	+0.046	+2.037	.004	.004	3	2
SKCM	SPATA31D5P →	+0.006	+2.007	<.001	<.001	3	2
BLCA	OR7E159P →	+0.161	+4.588	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 763 associations by consensus.

MIR4425 by OR4B1 expression — COAD

Explore this box plot interactively →