OR4B1

Across TCGA patient cohorts, OR4B1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible OR4B1-associated genes across cancer lineages are MEK1, Lck, and PARP_cleaved. Each is linked with OR4B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4B1-to-partner and partner-to-OR4B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by OR4B1-low versus OR4B1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4B1→partner) and Y-score (partner→OR4B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MEK1 →	-0.241	-2.983	.035	.036	3	2
SKCM	Lck →	-0.319	-3.000	.012	.034	3	1
SKCM	PARP_cleaved →	+0.119	+1.874	.046	.049	3	1
SKCM	PKC-delta_pS664 →	-0.147	-2.321	.039	.033	3	1
SKCM	Rb_pS807_S811 →	+0.367	+1.874	.026	.049	3	1
SKCM	Transglutaminase →	-0.143	-2.807	.034	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MEK1 by OR4B1 expression — LUAD

Explore this box plot interactively →