OR4B1

Across TCGA cell cohorts, OR4B1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible OR4B1-associated genes across cancer lineages are SPACA3, C4BPA, and C7orf33. Each is linked with OR4B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4B1-to-partner and partner-to-OR4B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPACA3 grouped by OR4B1-low versus OR4B1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4B1→partner) and Y-score (partner→OR4B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SPACA3 →	+0.125	+4.299	.002	.001	3	1
SKIN	C4BPA →	+0.033	+4.054	<.001	.004	3	1
SKIN	C7orf33 →	+0.069	+4.217	<.001	.001	3	1
SKIN	CYP26C1 →	+0.176	+3.906	<.001	.005	3	1
SKIN	SALL3 →	+0.457	+3.793	<.001	.007	3	1
STOMACH	MMP26 →	+0.673	+5.285	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

SPACA3 by OR4B1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →