OR4A15

Across TCGA patient cohorts, OR4A15 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4A15-associated genes across cancer lineages are 4E-BP1_pS65, S6, and c-Jun_pS73. Each is linked with OR4A15 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR4A15-to-partner and partner-to-OR4A15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pS65 grouped by OR4A15-low versus OR4A15-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4A15→partner) and Y-score (partner→OR4A15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	4E-BP1_pS65 →	+0.164	+2.821	.020	.035	3	3
SKCM	S6 →	+0.272	+1.125	.044	.030	3	3
LUSC	c-Jun_pS73 →	+0.193	+3.169	.011	.018	3	2
LUAD	Bcl-xL →	-0.254	-2.807	<.001	.003	2	3
SKCM	EGFR →	-0.134	-1.502	.006	.025	3	2
SKCM	mTOR →	+0.193	+1.321	.008	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

4E-BP1_pS65 by OR4A15 expression — LUSC

Explore this box plot interactively →