OR3A3

Across TCGA patient cohorts, OR3A3 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR3A3-associated genes across cancer lineages are ATM, Cyclin-E2, and EGFR_pY1068. Each is linked with OR3A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR3A3-to-partner and partner-to-OR3A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by OR3A3-low versus OR3A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR3A3→partner) and Y-score (partner→OR3A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.587	-3.308	.004	.009	3	2
UCEC	Cyclin-E2 →	+0.172	+2.179	.023	.034	3	2
UCEC	EGFR_pY1068 →	-0.394	-3.584	<.001	.002	3	1
UCEC	A-Raf_pS299 →	-0.168	-3.169	.001	.019	2	2
UCEC	FOXO3a_pS318_S321 →	-0.156	-3.160	.005	.019	3	1
UCEC	JNK2 →	+0.365	+3.807	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

ATM by OR3A3 expression — UCEC

Explore this box plot interactively →